The Daughters of Mary Help of Christians commonly known as Salesian Sisters of Don Bosco was founded by St. John Bosco and by St. Mary Domenica Mazzarello, the co-foundress on 5 August 1872 in Italy. There are 15,300 salesian sisters working in 89 countries in five continents of the Globe. The sisters came to India in 1922.

In 1992 Salesian sisters commenced to work for the first time in Malankara diocese, namely Tiruvalla. The very first house was opened at Kottayam - puthupally and the first Superior of the house is Sr. Rose Thomas. It was followed by Sr. Elizabeth George, Sr. Philo Fernandez, and Sr. Cecily Paul. The present Superior is Sr. Rosa E.J.

The second house in the diocese was opened in 1997 at Kattappana which is a fertile land of numerous activities. The following are the Superiors who led the work; Sr. Rosy Lopez, Sr. Rosamma Thonippara, and Sr. Mercy Ittoop. Sr. Rosa Challamkathil now holds the reins.